Increased liver stiffness measurement in patients with non-alcoholic fatty liver diseases might hints high-risk NASH
Objective The purpose of this study was to explore the diagnostic performance of FibroScan,magnetic resonance imaging proton density fat-fraction(MRI-PDFF)and FibroScan-AST(FAST)score in judging patients with high risk non-alcoholic steatohepatitis(NASH)from those with non-alcoholic fatty liver diseases(NAFLD).Mthods A total of 107 patients with NAFLD were encountered in our hospital between June 2017 and December 2021,and all patients underwent liver biopsies.FibroScan,MRI-PDFF and serological detection were completed and three non-invasive models of FAST,FIB-4 and APRI were calculated.Univariate and multivariate Logistic regression analysis was used to screen out factors impacting high-risk NASH.The diagnostic performance of relevant parameters and three non-invasive models to identify high risk NASH was analyzed by ROC curve.Result Of 107 patients with NAFLD,the histo-pathological examination showed high risk NASH in 13 cases(12.1％),and simple alcoholic fatty liver and non-high risk NASH in 94 cases(87.9％);liver stiffness measurement(LSM)by Fibroscan,FAST score and aspartate aminotransferase/platelets(APRI)in patients with high risk NASH were significantly higher than in those with non-high risk NASH(P＜0.05);multivariate Logistic regression analysis showed that only the LSM was the independent risk factor impacting high risk NASH(P＜0.05);ROC analysis demonstrated that the LSM,FAST and APRI could identify high risk NASH(P＜0.05),with AUCs of 0.795,0.713 and 0.682,and the LSM got the optimal diagnostic efficacy,with sensitivity(Se)and specificity(Sp)of 92.3％and 54.3％based on exclusion cut-off-value,and with Se and Sp of 53.8％and 90.4％based on inclusion cut-off-value.Conclusion The simultaneous increased LSM in patients with NAFLD hints existence of NASH,which might help clinicians make appropriate measures to tackle it.
Nonalcoholic SteatohepatitisFibroScanMagnetic resonance imaging proton density fat-fractionFAST scoreDiagnostic test
万方数据
维普
