Synthesis of 2-chloro-4-fluoro-5-nitrobenzaldehyde by microreactor
The optimal process for the synthesis of 2-chloro-4-fluoro-5-nitrobenzaldehyde by microreactor was as follows,the mass ratio of nitric acid to sulfuric acid was 1∶11,the re-action temperature was 40℃,the optimal flow rate of benzaldehyde-sulfuric acid mixed so-lution was 38 g/min,the optimal flow rate of nitro-sulfuric acid mixed solution was 41 g/min,and the content of 2-chloro-4-fluoro-5-nitrobenzaldehyde was more than 99.5%.
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