The study on the process of preparing 2-chloro-5-methylpyridine using mi-crochannel continuous flow technology,with solid phosgene as the chlorinating agent,the molar ratio of chlorinating agent to 3-methylpyridine oxide was 1.2∶1.0,the reaction temper-ature was 20℃,the salt-forming reaction residence time was 15 s,the salt solution was ob-tained,then the temperature was raised to 30℃,chlorine gas was introduced until the sys-tem pressure was 0.6 MPa,the chlorination reaction residence time was 180 s,the yield of 2-chloro-5-methylpyridine was highest at 93.6%.The conversion rate of 3-methylpyridine oxide was increased by 6.2%compared with the reactor reaction,the yield of 2-chloro-5-methylpyridine was increased by 8.8%,the total reaction time was shortened to 195 s,which demonstrated the excellent mass transfer and heat transfer characteristics of the microchan-nel continuous flow reactor,shortened the reaction time,and improved the reaction efficiency.
关键词
2-氯-5-甲基吡啶/微通道技术/工艺研究
Key words
2-chloro-5-methylpyridine/microchannel technology/process research
维普
万方数据