Comprehensive experimental design of mineral medicine pyritum photothermal nanomaterials preparation and photothermal performance research
[Objective]Photothermal materials are materials that have strong absorption in the near-infrared region(760-1500 nm)and can convert the absorbed near-infrared light energy into heat,which have potential applications in the fields of energy conversion,photothermal imaging,bacterial infections,and photothermal treatment of tumors.However,the current preparation process of inorganic nano-photothermal materials has the problems of high cost,cumbersome synthesis process with long cycle time,and biocompatibility and cytotoxicity which bring some difficulties for clinical applications.In this paper,we propose to prepare near-infrared inorganic nanomaterials from pyritum(FeS2),a mineral drug included in the Chinese Pharmacopoeia,which has low cost,simple preparation process,abundant raw material sources,and excellent biocompatibility.Pyritum has the efficacy of dispersing blood stasis,relieving pain,renewing tendons and bones,and is mostly used for the treatment of bruises and injuries,tendon and bone fractures,bruises and pain,and it is one of the commonly used medicines in Chinese medicine for injuries in all the editions of Chinese Pharmacopoeia,which was firstly contained in Leigong Baozhi Lun in North and South Dynasties period,and has been used for more than 1,000 years,and there has not yet been any report on the preparation of nano-pyrophotothermal nanomaterials from the Chinese traditional Chinese medicine pyritum.[Methods]In this paper,the pyritum was calcined and then quenched in vinegar solution,after which it was finely ground into powder,which was mixed with surfactant F127 solution and put into ball mill for ball milling,and after ball milling,the powder was subjected to magnetic separation of impurities,and freeze-drying,which resulted in the desired photothermal nanomaterials of the mineral medicine pyritum.[Results]The prepared calcined pyritum nanoparticles are Fe7S8-dominated physical phase with Fe content of 60.62％at the calcination temperature of 800 ℃,and have excellent light absorption properties in the wavelength range of 300 nm-800 nm,The pyritumprocessed product formed by roasting and vinegar quenching at 800 ℃ has many honeycomb and bubble-like protrusions and faults by acetic acid erosion,and is more easily crushed than the raw product.After ball milling for 6 h,the nanoparticles showed a hydrodynamic size of about 374.99 nm,an irregular spherical-like structure,and still in the physical phase of Fe7S8.Under the irradiation condition of near-infrared 808 nm wavelength light with a power of 0.39 W/cm2,the temperature of the surface of the nanomaterials could be increased to 130.0 ℃ in 5 min,so they have an excellent photothermal effect.In the near-infrared five-cycle photothermal conversion experiments,the temperature of the 1st laser irradiated powder increased from 33.5 ℃ to 51.4 ℃ after 5 min;the temperature of the powder could be increased to～51 ℃ or so after 5 min of laser irradiation from the 2nd to the 5th time,which indicated that the photothermal performance of the concoction nanoparticles prepared by the pyritun fire calcination and vinegar quenching and ball milling and magnetic separation was stable.[Conclusion]This low-cost,simple preparation and synthesis process,good biocompatibility and excellent photothermal conversion ability of pyritum nanophotothermal materials have great potential for future applications in the biomedical field.
TCM(traditional Chinese medicine)processingmineral medicinepyritumphotothermalnano
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