黑木耳多糖-麦角甾醇复合物制备及体外降胆固醇作用
Preparation of Auricularia auricula Polysaccharide-Ergosterol Complex and Its Cholesterol-Lowering Effect In vitro
李梁 1李佳辉 1吴佳蔓 1王哲铭 1贾丰荧 1靳雯 1云少君 1冯翠萍1
作者信息
- 1. 山西农业大学食品科学与工程学院,山西晋中 030801
- 折叠
摘要
采用反溶剂法制备黑木耳(Auricularia auricula)多糖-麦角甾醇复合物(APE),对其微观形态、结构特征和光、热稳定性进行分析,并研究其对胆固醇在胶束中溶解度的影响.结果表明:麦角甾醇与黑木耳多糖质量比为1:16时,麦角甾醇的包封率最高;在此条件下制备的APE表面粗糙,呈纤维状,平均粒径为1 265 nm.与游离麦角甾醇相比,APE光、热稳定性均较好.APE能够显著降低胆固醇胶束的溶解度.研究结果可为黑木耳多糖和麦角甾醇的进一步开发利用提供参考.
Abstract
Polysaccharides in Auricularia auricula were obtained by water extraction and alcohol precipitation,and then used to prepare A.auricula polysaccharide-ergosterol(APE)complex by the antisolvent method.The complex was observed for microstructure,analyzed for structural characteristics and photothermal stability,and determined for its effect on cholesterol solubility in micelles.The results showed that ergosterol encapsulation efficiency reached the highest when the mass ratio of ergosterol to A.auricula polysaccharides was 1:16.The APE prepared at this mass ratio had a rough and fibrous surface,and its average particle size was 1 265 nm.Compared with free ergosterol,APE showed better photothermal stability.APE significantly reduced the solubility of cholesterol in micelles.These results provided a theoretical basis for further development and utilization of A.auricula polysaccharides and ergosterol.
关键词
黑木耳/多糖/麦角甾醇/表征/稳定性/降胆固醇Key words
Auricularia auricula/polysaccharide/ergosterol/characterization/stability/cholesterol-lowering引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据