Preparation of Auricularia auricula Polysaccharide-Ergosterol Complex and Its Cholesterol-Lowering Effect In vitro
Polysaccharides in Auricularia auricula were obtained by water extraction and alcohol precipitation,and then used to prepare A.auricula polysaccharide-ergosterol(APE)complex by the antisolvent method.The complex was observed for microstructure,analyzed for structural characteristics and photothermal stability,and determined for its effect on cholesterol solubility in micelles.The results showed that ergosterol encapsulation efficiency reached the highest when the mass ratio of ergosterol to A.auricula polysaccharides was 1:16.The APE prepared at this mass ratio had a rough and fibrous surface,and its average particle size was 1 265 nm.Compared with free ergosterol,APE showed better photothermal stability.APE significantly reduced the solubility of cholesterol in micelles.These results provided a theoretical basis for further development and utilization of A.auricula polysaccharides and ergosterol.
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