首页|生物钟基因调控干细胞分化的研究进展

生物钟基因调控干细胞分化的研究进展

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生物钟在各类生物中广泛存在,调节生物体的各项生理活动,其主要依赖于生物钟基因的节律性表达.生物钟基因在多种生理过程中发挥重要作用,其中已被证明与组织再生密切相关.干细胞是再生医学的着重关注点,调控干细胞定向分化可实现组织修复再生.已有研究表明生物钟基因是调控干细胞分化的关键因素,因此靶向生物钟基因显示出一定的治疗前景.该文对近年生物钟基因在多种干细胞分化过程中的调控作用及其相关机制研究进行阐述和分析,为再生医学应用方向提供可能思路.
Research progress of circadian clock genes regulating stem cell differentiation
Circadian clock exists widely in all kinds of organisms and regulates various physiological activities of organisms,which mainly depends on the rhythmic expression of circadian clock genes.Circadian clock genes play an important role in many physiologi-cal processes,which has been shown to be closely related to tissue regeneration.Stem cells are the focus of regenerative medicine,and the regulation of stem cells directed differentiation can achieve tissue repair and regeneration.Studies have shown that circadian clock genes are the key factors regulating stem cell differentiation,so targeting circadian clock genes shows certain therapeutic prospects.In this review,the research progress of the regulation of circadian clock genes in the differentiation of stem cells and their related mecha-nisms is introduced and analyzed to provide possible ideas for the future application of regenerative medicine.

Circadian clockStem cellDifferentiationRegulation mechanism

郑佳南、宫苹

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610041 成都,口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医院种植科

生物钟基因 干细胞 分化 调控机制

国家自然科学基金

82170935

2024

实用口腔医学杂志
第四军医大学口腔医学院

实用口腔医学杂志

CSTPCD北大核心
影响因子:0.942
ISSN:1001-3733
年,卷(期):2024.40(2)
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