左氧氟沙星治疗口腔颌面部间隙感染致过敏性休克1例
A case of levofloxacin-induced anaphylactic shock in a patient with oral and maxillofacial space infection
郭志刚 1房秀梅 2杨建森 1贾天祺 1郑利光1
作者信息
- 1. 100081,北京大学口腔医学院·口腔医院药剂科,国家口腔医学中心,国家口腔疾病临床医学研究中心,口腔生物材料和数字诊疗装备国家工程研究中心
- 2. 北京中医药大学东直门医院药学部
- 折叠
摘要
口腔颌面部间隙感染(OMSI)多为混合感染,常需要抗需氧菌和抗厌氧菌药物联合治疗.左氧氟沙星等第三代喹诺酮类抗菌药物因肌腱断裂等严重不良反应限制了在OMSI中使用.该研究利用药品不良反应关联性评价方法和文献研究法,针对1例临床药师参与的OMSI患者使用左氧氟沙星后发生过敏性休克的病例进行分析,给出了合理用药和不良反应处理建议,为临床快速辨析不良反应及可疑药物、确定应对方案提供借鉴,完善OMSI用药选择,及时救治了休克,有效地治愈了 OMSI.
Abstract
Oral and maxillofacial space infection(OMSI)as a mostly mixed infection,often requires the combination of anti-aerobe and an-ti-anaerobe antibiotics.The use of third-generation quinolones,such as levofloxacin,is limited in OMSI due to the tendon rupture and other serious adverse drug reactions(ADR).In the treatment of a case with OMSI and anaphilactic shock induced by levofloxacin,the association evaluation method of ADR and literature review method participated by clinical pharmacists were used.Suggestions on rational drug use and ADR treatment were gained,the patient was timely rescued from anaphylactic and cured of OMSI.
关键词
左氧氟沙星/过敏性休克/颌面间隙感染/药物不良反应Key words
Levofloxacin/Anaphylactic shock/Oral and maxillofacial space infection/Adverse drug reaction引用本文复制引用
基金项目
北京市自然科学基金资助项目(9204031)
北京大学口腔医(学)院管理科研基金(2023GLIJ10)
出版年
2024
NETL
NSTL
万方数据