牙周-正畸治疗对牙周炎致前牙移位患者牙周指标、骨代谢及血清sICAM-1、MCP-1水平的影响
The impacts of periodontal-orthodontic treatment on periodontal indicators,bone metabolism and serum sICAM-1 and MCP-1 levels in patients with anterior tooth displacement(ATD)caused by periodontitis
蔡晨雨 1李媛媛 1李苏娜1
作者信息
- 1. 053000,衡水市人民医院口腔正畸修复科
- 折叠
摘要
目的:探讨牙周-正畸治疗对牙周炎致前牙移位(ATD)患者牙周指标、骨代谢及血清人可溶性细胞间黏附分子(sICAM-1)、单核细胞趋化蛋白-1(MCP-1)水平的影响.方法:纳入60例牙周炎致ATD患者,随机分成对照组(n=30,牙周基础治疗+牙周夹板治疗)和牙周-正畸组(n=30,在对照组基础上联合正畸治疗).另选取仅进行牙周基础治疗的31例ATD患者作为空白对照组.比较3组牙周探诊深度(PD)、菌斑指数(PLI)和牙龈指数(GI)、患牙松动度、骨代谢指标骨钙素(OCN)、护骨素(OPG)及血清炎症指标(sICAM-1、MCP-1).结果:治疗6个月后,3组PD、PLI、GI及血清sICAM-1、MCP-1水平均低于治疗前(P＜0.05),且牙周-正畸组均低于对照组、空白对照组(P＜0.05);3组患牙松动度均优于治疗前(P＜0.05),且牙周-正畸组优于对照组、空白对照组(P＜0.05);3组OCN、OPG水平均高于治疗前(P＜0.05),且牙周-正畸组均高于对照组、空白对照组(P＜0.05).结论:对牙周炎致ATD患者实施牙周-正畸治疗,可明显下调血清sICAM-1、MCP-1等炎症因子水平,有效调节骨代谢,使患者牙周功能得到良好改善.
Abstract
Objective:To investigate the impacts of periodontal-orthodontic treatment on periodontal indicators,bone metabolism and serum levels of soluble intercellular adhesion molecule-1(sICAM-1)and monocyte chemotactic protein-1(MCP-1)in patients with an-terior tooth displacement(ATD)caused by periodontitis.Methods:60 patients with ATD caused by periodontitis were included and randomly divided into a reference group(n=30,periodontal basic treatment+periodontal splint treatment)and a study group(n=30,combination of orthodontic treatment with the reference treatment).31 ATD patients who only received periodontal basic treatment were included into the blank control group.The probing depth(PD),plaque index(PLI)and gingival index(GI),tooth looseness,bone me-tabolism indicators osteocalcin(OCN)and osteoprotegerin(OPG),and serum inflammatory indicators(sICAM-1 and MCP-1)were compared among the 3 groups before and after treatment.Results:After 6 months of treatment,the levels of PD,PLI,GI,and serum sICAM-1 and MCP-1 in the 3 groups were lower than those before treatment(P＜0.05),and lower in the study group than in the refer-ence group and blank control group(P＜0.05);the looseness of the affected teeth in the 3 groups was decreased(P＜0.05),and in the study group was less than in the reference group and blank control group(P＜0.05);the levels of OCN and OPG in the 3 groups were higher(P＜0.05)than those before treatment,and in the study group were higher than in the reference group and blank control group(P＜0.05).Conclusion:Periodontal-orthodontic treatment can obviously reduce the levels of inflammatory factors in serum,effectively regulate bone metabolism and improve periodontal health in patients with ATD caused by periodontitis.
关键词
牙周夹板/正畸/牙周炎/前牙移位/骨代谢/牙周炎症Key words
Periodontal splints/Orthodontics/Periodontitis/Anterior tooth displacement/Bone metabolism/Pe-riodontitis引用本文复制引用
基金项目
衡水市科技计划项目(2021014093Z)
出版年
2024
NETL
NSTL
万方数据