Comparison of the Efficacy of Ketamine and Sufentanil Combined with Dexmedetomidine in Percutaneous Vertebroplasty
Objective To compare the efficacy of esketamine versus sufentanil combined with dexmedetomidine on intravenous analgesia,sedation and safety in elderly patients undergoing per-cutaneous vertebroplasty(PVP).Methods Using prospective research methods,Sixty elderly pa-tients who underwent PVP with osteoporosis vertebral compression fracture were assigned ran-domly into SD group(sufentanil+dexmedetomidine group,n=30)and KD group(esketamine+dexmedetomidinegroup,n=30).SD group was given 0.1 μg·kg-1intravenous injection,and KD group was given esketamine 0.3 mg·kg-1intravenous injection,followed by dexmedetomidine 0.5 µg·kg-1·h-1 continuous pumping in both.Compare the mean arterial pressure(MAP),heart rate(HR),blood oxygen saturation(SPO2),pain level VAS score and Ramsay sedation score of the 2 groups at 5 time points:T1(before drug administration),T2(5 min after administration of sufentanil or esketamine),T3(15 min after administration of sufentanil or esketamine),T4(30 min after administration of sufentanil or esketamine),and T5(before discharge from the op-erating room);and observe the adverse effects of the patients in 2 groups,including blood pres-sure fluctuation,cardiac arrhythmia,respiratory depression,nausea and vomiting,psychotic symp-toms such as balderdash and agitation.Results Compared with SD group,KD group had signifi-cantly higher MAP and HR at T3 and T4,significantly higher Ramsay sedation scores atT2,T3,and T4,and significantly lower VAS pain scores at T3 and T4,and the differences were all statis-tically significant(P＜0.05).There was no significant difference in the incidence of adverse reac-tions between the two groups(P＞0.05).Conclusion Low-dose esketamine combined with dexmedetomidine in percutaneous vertebroplasty may produce good analgesia and sedation,with smoot-her vital signs,and may be a clinically safe and feasible combination of anesthesia medications.
万方数据
维普
