Objective To compare the efficacy of esketamine versus sufentanil combined with dexmedetomidine on intravenous analgesia,sedation and safety in elderly patients undergoing per-cutaneous vertebroplasty(PVP).Methods Using prospective research methods,Sixty elderly pa-tients who underwent PVP with osteoporosis vertebral compression fracture were assigned ran-domly into SD group(sufentanil+dexmedetomidine group,n=30)and KD group(esketamine+dexmedetomidinegroup,n=30).SD group was given 0.1 μg·kg-1intravenous injection,and KD group was given esketamine 0.3 mg·kg-1intravenous injection,followed by dexmedetomidine 0.5 µg·kg-1·h-1 continuous pumping in both.Compare the mean arterial pressure(MAP),heart rate(HR),blood oxygen saturation(SPO2),pain level VAS score and Ramsay sedation score of the 2 groups at 5 time points:T1(before drug administration),T2(5 min after administration of sufentanil or esketamine),T3(15 min after administration of sufentanil or esketamine),T4(30 min after administration of sufentanil or esketamine),and T5(before discharge from the op-erating room);and observe the adverse effects of the patients in 2 groups,including blood pres-sure fluctuation,cardiac arrhythmia,respiratory depression,nausea and vomiting,psychotic symp-toms such as balderdash and agitation.Results Compared with SD group,KD group had signifi-cantly higher MAP and HR at T3 and T4,significantly higher Ramsay sedation scores atT2,T3,and T4,and significantly lower VAS pain scores at T3 and T4,and the differences were all statis-tically significant(P＜0.05).There was no significant difference in the incidence of adverse reac-tions between the two groups(P＞0.05).Conclusion Low-dose esketamine combined with dexmedetomidine in percutaneous vertebroplasty may produce good analgesia and sedation,with smoot-her vital signs,and may be a clinically safe and feasible combination of anesthesia medications.
维普
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