EGR-1和MMP-2在早期自然流产患者中的表达及临床意义

The Expression and Clinical Significance of EGR-1 and MMP-2 in Patients with Early Spontaneous Abortion

丁书军 ¹黄丽霞 ¹熊雪 ¹黄宁²

扫码查看

作者信息

1. 江西省妇幼保健院检验科,南昌 330006
2. 江西省妇幼保健院医学遗传中心,南昌 330006
折叠

摘要

目的探讨早期生长反应因子(EGR-1)和基质金属蛋白酶-2(MMP-2)在早期自然流产患者绒毛中的表达及临床意义.方法采用RT-PCR和Westernblot检测20例早期自然流产患者(流产组)和20例正常早孕人工流产(对照组)绒毛组织中EGR-1和MMP-2的表达情况.结果流产组中EGR-1、MMP-2 mRNA和蛋白水平明显低于对照组,差异有统计学意义(P＜0.05).结论 EGR-1和MMP-2在早孕绒毛组织中表达异常可能参与早期妊娠失败的发生.

Abstract

Objective To investigate the expression and clinical significance of early growth re-sponse factor(EGR-1)and matrix metalloproteinase-2(MMP-2)in the villi of patients with early spontaneous abortion.Methods RT-PCR and Westernblot were used to detect the expression of EGR-1 and MMP-2 in the chorionic villus tissues of 20 patients with early spontaneous abortion(abortion group)and 20 normal early pregnancy abortions(control group).Results The levels of EGR-1,MMP-2 mRNA and protein in the abortion group were significantly lower than those in the control group,and the difference was statistically significant(P＜0.05).Conclusion Abnor-mal expression of EGR-1 and MMP-2 in early pregnancy chorionic tissue may be involved in the development of early pregnancy failure.

关键词

早期生长反应因子-1/基质金属蛋白酶-2/自然流产

Key words

early growth response factor-1/matrix metalloproteinase-2/spontaneous abortion

引用本文复制引用

基金项目

江西省卫健委科技计划(202130770)

江西省中医药管理局科技计划(2020B0343)

江西省卫健委科技计划(202211059)

江西省科技厅应用研究培育计划(20181BBG78005)

出版年

2024

实用临床医学

南昌大学

实用临床医学

影响因子：0.818

ISSN：1009-8194

参考文献量20

段落导航