Clinical Value of Combined CD97,CD55 and C1q Testing in Differential Diagnosis of TPE and MPE
Objective To investigate the clinical value of combined CD97,CD55 and C1q testing in differential diagnosis of tuberculous pleural effusion(TPE)and malignant pleural effusion(MPE).Methods A total of 150 patients with pleural effusion(PE)admitted to the First Affilia-ted Hospital of Gannan Medical College from January 2023 to December 2023 were selected as the study objects.According to pathological diagnosis,they were divided into the TPE group(78 ca-ses)and the MPE group(72 cases);the levels of CD97,CD55 and C1q were compared between the two groups.The application value of CD97,CD55,C1q and their combined detection were ana-lyzed in the differential diagnosis of TPE and MPE.Results There was no statistically significant difference in age,gender,smoking history,diabetes history,pleural nodules,pleural thickness,fe-ver,chest pain between the two groups(P＞0.05).The levels of CD97 and C1q in the MPE group were lower than those in the TPE group,whereas the levels of CD55 were higher than those in the TPE group(P＜0.05).ROC curve analysis showed that CD97 had an AUC of 0.718 in the differ-ential diagnosis of TPE and MPE,with 113.53 ng·mL-1 as the threshold value,and its sensitivi-ty and specificity were 69.44％and 70.51％;CD55 had an AUC of 0.735 in the differential diag-nosis of TPE and MPE,with 69.43 ng·mL-1 as the threshold value,and its sensitivity and speci-ficity were 81.94％and 55.13％;C1q had an AUC of 0.690 in the differential diagnosis of TPE and MPE,with 8.91 mg·L-1 as the threshold value,and its sensitivity and specificity were 98.61％and 38.46％.CD97,CD55 and C1q combined had an AUC of 0.753 in the differential diag-nosis of TPE and MPE,and its sensitivity and specificity were 58.33％and 92.31％.Conclusion CD97,CD55 and C1q can have some clinical value in differential diagnosis of TPE and MPE,and the combined test of CD97,CD55 and C1Q can have greater diagnostic value and higher specificity.
tub erculous pleural effusionmalignant pleural effusionthe complement systemCD97CD55
NETL
NSTL
万方数据
维普
