Clinical Efficacy of Chymotrypsin Combined with Terbutaline Nebulization in Bronchial Asthma
Objective To investigate the efficacy of chymotrypsin combined with terbutaline nebulization in the management of bronchial asthma and its effect on lung function,inflammatory factors,and immunoglobulin levels.Methods 80 patients with bronchial asthma were randomly divided into the control group and the observation group,40 cases in each group.On the basis of conventional treatment for both groups,the control group was further given terbutaline nebuliza-tion whereas the observation group was given chymotrypsin combined with terbutaline nebuliza-tion treatment.Clinical efficacy,clinical symptom disappearance time,pulmonary function indexes[forceful expiratory volume in the first second(FEV1),FEV1/forceful lung capacity(FVC),ex-haled nitric oxide(FENO)],serum inflammatory factors[ECP,IFN-γ,interleukin-4(IL-4),inter-leukin-1β(IL-1β),hypersensitive C-reactive protein(hs-CRP)],and immunoglobulin levels[im-munoglobulin A(IgA),immunoglobulin M(IgM),immunoglobulin G(IgG),immunoglobulin E(IgE)]were compared before and after the treatment between the two groups.The occurrence of adverse reactions was observed in the 2 groups.Results The total effective rate of the observation group was higher than that of the control group(P＜0.05).Symptom disappearance time of the observation group was shorter than that of the control group(P＜0.05).The FENO value and ser-um ECP,IL-4,IL-1β,hs-CRP,IgE levels of the two groups were significantly lower after treat-ment than those before treatment;the FEV1,FEV1/FVC values and serum IFN-γ,IgA,IgM,IgG levels were significantly higher than those before treatment;the above indexes of the observation group were more significantly improved after treatment than those of the control group,and the differences were statistically significant(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Chymotryp-sin combined with terbutaline nebulization might be effective in the management of bronchial asthma,which can positively alleviate clinical symptoms,promote pulmonary function,improve inflammatory response and immune function in a short period of time,with relatively good safety.
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