Clinical Effect of Troxerutin Combined with Betahistine on ACI Patients
Objective To analyze the clinical effect of troxerutin combined with betahistine on neurological function and hemorheology in patients with acute cerebral infarction(ACI).Methods A total of 100 patients with ACI admitted to our hospital from June 2020 to June 2023 were se-lected for the study,and were divided into the control group(50 cases)and the observation group(50 cases)using the random envelope method.Apart from conventional treatment for both groups,the control group was further given betahistine while the observation group was given troxerutin and betahistine.The clinical efficacy,the scores of the National Institute of Health Stroke Scale(NIHSS)and Mini-mental State examination(MMSE),the levels of neurotrophic fac-tors[insulin-like growth factor-1(IGF-1)and brain-derived neurotrophic factor(BDNF)],the blood rheology indexes[plasma viscosity(PSV),fibrinogen(FIB),whole blood viscosity high cut(HSV),platelet adhesion rate(PAR)and whole blood viscosity low cut(LSV)],levels of inflam-matory factors[interleukin(IL)-6,ultrasensitive C-reactive protein(hs-CRP)and tumor necrosis factor-alpha(TNF-alpha)],and the occurrence of adverse reactions were compared between the two groups.Results The clinical efficacy of the observation group was 94.00％,higher than 78.00％of the control group;the difference was statistically significant(P＜0.05).Compared with the control group,the NIHSS of the observation group was lower after treatment,and the IGF-1,MMSE and BNDF were higher;the differences were statistically significant(P＜0.05).After treatment,the levels of IL-6,PAR,FIB,hs-CRP,PSV,HSV,TNF-α and LSV in the two groups were significantly decreased,and those in the observation group were lower than those in the con-trol group(P＜0.05).There was no significant difference in the incidence of adverse reactions be-tween the two groups(P＞0.05).Conclusion Troxerutin combined with betahistine can be safe and effective in the management of ACI patients,which can inhibit the secretion of inflammatory mediators,promote the recovery of blood flow and nerve function,and is beneficial to the progno-sis of patients.
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