Objective To investigate the diagnostic value of β-2 microglobulin(beta-2 MG),neutrophil-to-lymphocyte ratio(NLR),and total prostate-specific antigen(tPSA)in prostate canc-er(PCa)patients with elevated prostate-specific antigen(PSA).Methods 210 patients who under-went prostate biopsy or transurethral resection of the prostate by electrocautery(TURP)from May 2020 to December 2023 and had a tPSA level over 4 ng·mL-1 were chosen and divided into benign prostatic hyperplasis(BPH)group(n=110)and PCa group(n=100)according to the pathologic diagnosis.Logistic regression and ROC curve analysis were used to evaluate the diagnosis value of single and/or multiple indicators in PCa from patients with high PSA.Results The levels of tPSA,free prostate-specific antigen,neutrophils,β-2 MG,and NLR were higher in the PCa group than in the BPH group(P＜0.05);prostate volume and lymphocyte levels were lower in the PCa group than in the BPH group(P＜0.05).tPSA,β-2 MG and NLR were independent risk factors for the development of PCa and the diagnosis efficiency of the combined detection of those three factors was higher than that of single factor and of pairwise factors.Conclusion High diagnostic value could be observed in the combined detection of tPSA,β-2 MG and NLR,which suggests that it might allow early diagnosis of whether a patient with elevated PSA has PCa.
NETL
NSTL
维普
万方数据
