TACE with Drug-loaded Microspheres and TACE with Iodine Oil in Unresectable Hepatocellular Carcinoma
Objective To compare clinical efficacy of transarterial chemoembolization(TACE)with drug-loaded microspheres and TACE with iodine oil in the management of unresectable hep-atocellular carcinoma.Methods A total of 70 patients with unresectable hepatocellular carcinoma admitted from October 2020 to October 2023 were subjected to TACE.According to the TACE embolic agent,they were divided into the drug-loaded microsphere TACE(DEB-TACE)group(36 patients,with CalliSpheres drug-loaded microspheres)and iodized oil TACE(c-TACE)group(34 patients,with iodized oil).Clinical outcomes,liver function indices[alanine aminotransferase(ALT),total bilirubin(TBiL),and glutamic transaminase(AST)]and the incidence of complica-tions(vomiting,fever,moderate-to-severe abdominal pain,and acute hepatic dysfunction)were compared between the 2 groups at 6 months postoperatively.Results The DCR rate of the obser-vation group was higher than that of the control group(88.89％vs 67.65％,P＜0.05);the postop-erative levels of ALT,TBiL,and AST were higher than those of the preoperative period in the two groups(P＜0.05),but the levels of ALT,AST,and TBiL in the DEB-TACE group were low-er than those in the c-TACE group(P＜0.001);the differences in the complication rates of the 2 groups were not statistically significant(P＞0.05).Conclusion DEB-TACE might be more effec-tive than c-TACE in managing unresectable hepatocellular carcinoma,exerting less impact on liv-er functions without increasing complications.
unresectable hepatocellular carcinomatransarterial chemoembolization with drug-loaded microspheretransarterial chemoembolization with iodine oil
NETL
NSTL
万方数据
