Objective To investigate the effects of transdermal estradiol gel and oral estradiol tablets on clinical outcomes of frozen embryo transfer(FET)in older women.Methods The clini-cal data of 391 older(≥38 years old)female patients who underwent FET at the Center for Assis-ted Reproduction of Jiangxi Maternal and Child Health Hospital from January 2021 to July 2022 were retrospectively analyzed;the patients who used estradiol gel percutaneously and externally in endothelial preparations were classified as the estradiol gel group(n=192),and the patients who took estradiol valerate tablets orally were classified as the oral estradiol group(n=199);the clinical characteristics of the 2 groups were compared.Results There were no statistically signifi-cant differences in age,body mass index,sinus follicle count,and anti-mullerian hormone between the 2 groups(P＞0.05),and there were no statistically significant differences in treatment(endo-thelial thickness on the day of conversion,coagulation function,and hepatic function)and clinical outcomes(HCG-positive rate,biochemical miscarriage rate,clinical pregnancy rate,multiple preg-nancy rate,implantation rate,miscarriage rate,and live-birth rate)(P＞0.05).Conclusion Trans-dermal estradiol gel and oral estradiol tablet might have similar clinical outcomes during FET pregnancy assistance in older women,both with a desirable safety profile.
transdermal estradiol geloral estradiol tabletolder womanfrozen embryo transfer
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