Effects of Two Routes of Estrogen Administration on Clinical Outcomes of Frozen Embryo Transfer in Older Women
Objective To investigate the effects of transdermal estradiol gel and oral estradiol tablets on clinical outcomes of frozen embryo transfer(FET)in older women.Methods The clini-cal data of 391 older(≥38 years old)female patients who underwent FET at the Center for Assis-ted Reproduction of Jiangxi Maternal and Child Health Hospital from January 2021 to July 2022 were retrospectively analyzed;the patients who used estradiol gel percutaneously and externally in endothelial preparations were classified as the estradiol gel group(n=192),and the patients who took estradiol valerate tablets orally were classified as the oral estradiol group(n=199);the clinical characteristics of the 2 groups were compared.Results There were no statistically signifi-cant differences in age,body mass index,sinus follicle count,and anti-mullerian hormone between the 2 groups(P＞0.05),and there were no statistically significant differences in treatment(endo-thelial thickness on the day of conversion,coagulation function,and hepatic function)and clinical outcomes(HCG-positive rate,biochemical miscarriage rate,clinical pregnancy rate,multiple preg-nancy rate,implantation rate,miscarriage rate,and live-birth rate)(P＞0.05).Conclusion Trans-dermal estradiol gel and oral estradiol tablet might have similar clinical outcomes during FET pregnancy assistance in older women,both with a desirable safety profile.
transdermal estradiol geloral estradiol tabletolder womanfrozen embryo transfer
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