Objective To explore the clinical significance of impulse oscillometry(IOS)pulmo-nary function test in the diagnosis of asthma in preschool children.Methods 96 preschool children with asthma were established as the study group and 96 healthy children were selected as the con-trol group;the IOS pulmonary function test parameters[total respiratory viscous resistance(R5),peripheral airway viscous resistance(R5-R20),central airway viscous resistance(R20),and resonance frequency(Fres)],and conventional pulmonary function indices[forceful lung volume(FVC),peak expiratory flow rate(PEF),exertional expiratory volume in the first second(FEV1)]were compared between the two groups.The children in the study group were divided into mild,moderate and severe groups according to the degree of acute asthma exacerbation;the IOS pul-monary function test parameters,asthma control test(ACT)scores,and conventional lung func-tion indexes of the children with different degrees of asthma were compared;the relationship be-tween the IOS pulmonary function test parameters and ACT scores and conventional lung func-tion indexes was analyzed.Results R5,R5-R20,Fres,and R20 of the study group were signifi-cantly higher than those of the control group(P＜0.001);FVC,PEF,and FEV1 were significant-ly lower than those of the control group(P＜0.001).R5,R5-R20,Fres and R20 of the study group increased with the aggravation of asthma,whereas FVC,PEF,FEV1 and ACT scores decreased with the aggravation of the disease;the differences of the above indexes were statistically signifi-cant when compared between the children with different degrees of asthma(P＜0.001).The pa-rameters of the IOS pulmonary function tests suggested a significant negative correlation with the ACT scores and the conventional pulmonary function indexes(P＜0.05).Conclusion The param-eters of IOS pulmonary function test might change with the development of asthma in preschool children,and its application might be clinically significant in the diagnosis and efficacy monitoring of asthma in preschool children.
asthmapreschool childrenimpulse oscillometry pulmonary function testasthma control test scoreconventional pulmonary function
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