Microbial Metabolites Short-chain Fatty Acids in Parkinson's Disease:a Review
Parkinson's disease(PD)is a neurodegenerative disease pathologically characterized by nigrostriatal neuronal degeneration and a-synuclein(a-syn)aggregation,and there is a great correlation between its pathological mechanisms and gut microorganisms,especially its metabolite short-chain fatty acids(SCFAs),which play an important role in the occurrence and development of PD.Various SCFAs can exert neuroprotective effects on PD through gut barrier,inflammatory response,oxidative stress,apoptosis and autophagy.This article provides a review of recent re-search advances regarding the changes in the levels and mechanisms of action of SCFAs in PD pa-tients.
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