微生物代谢产物短链脂肪酸在帕金森病中的研究进展
Microbial Metabolites Short-chain Fatty Acids in Parkinson's Disease:a Review
林铭 1郭灿辉 2徐春艳 2涂怀军2
作者信息
- 1. 南昌大学第二附属医院神经内科,南昌 330006
- 2. 南昌大学第二附属医院老年医学科,南昌 330006
- 折叠
摘要
帕金森病(PD)是一种以黑质神经元变性及α-突触核蛋白(α-syn)聚集为病理特点的神经退行性疾病,其病理机制与肠道微生物之间存在极大关联,特别是其代谢产物短链脂肪酸(SCFAs)在PD的发生、发展中起重要作用.各类SCFAs可从肠道屏障、炎症反应、氧化应激、凋亡与自噬等途径对PD发挥神经保护作用.文章对关于SCFAs在PD患者体内的水平变化及作用机制的最新研究进展进行综述.
Abstract
Parkinson's disease(PD)is a neurodegenerative disease pathologically characterized by nigrostriatal neuronal degeneration and a-synuclein(a-syn)aggregation,and there is a great correlation between its pathological mechanisms and gut microorganisms,especially its metabolite short-chain fatty acids(SCFAs),which play an important role in the occurrence and development of PD.Various SCFAs can exert neuroprotective effects on PD through gut barrier,inflammatory response,oxidative stress,apoptosis and autophagy.This article provides a review of recent re-search advances regarding the changes in the levels and mechanisms of action of SCFAs in PD pa-tients.
关键词
帕金森病/短链脂肪酸/综述Key words
Parkinson's disease/short-chain fatty acid/review引用本文复制引用
基金项目
南昌大学第二附属医院院内资助临床研究项目(2021efyC06)
出版年
2024
NETL
NSTL
万方数据