Objective To evaluate the safety and efficacy of holmium laser lithotripsy with Moses technology in the management of patients with impacted ureteral stones.Methods A retrospective analysis was conducted on the clinical data of 70 patients with impacted ureteral stones admitted from July 2022 to July 2023,including 28 patients(the observation group)who underwent Moses holmium laser lithotripsy and 42 patients(the control group)who underwent conventional holmium laser lithotripsy.The duration of surgery,hospital stay,the incidence of postoperative complications,stone clearance rate,and the incidence of ureteral stricture were compared between the 2 groups.Results All 70 patients successfully completed the surgery.The operation time in the observation group was shorter than that in the control group[(39.57±13.15)minutes vs(46.31±13.23)minutes,P=0.04],and the incidence of postoperative complications was lower in the observation group(17.9%vs 47.6%,P=0.01).There were no statistically significant differences between the 2 groups in terms of postoperative hospital stay,stone clearance rate,and the incidence of ureteral stricture(P>0.05).Conclusions Our study suggests that holmium laser lithotripsy with Moses technology requires shorter operation time and has a lower incidence of postoperative complications in the management of patients with impacted ureteral stones.