Blood Trace Element Levels and Papillary Thyroid Carcinoma:a Correlational Study
Objective To evaluate the correlation between blood trace element levels and papillary thyroid carcinoma and to screen for pathogenic factors.Methods 168 Patients hospitalized in Shanghai Fengxian District Central Hospital for papillary thyroid cancer from October 2017 to October 2021 were established as the experimental group,and 156 healthy individuals from physical examination population were categorized as the control group;venous blood samples were collected;the commonly used chemiluminescence method was used to determine thyroid function and thyroid autoantibodies,and the inductively coupled plasma emission spectrometry was use to measure the levels of 8 essential trace elements(iodine,zinc,selenium,copper,molybdenum,chromium,cobalt,and iron);the differences between the 2 groups were compared and logistic regression analysis was used to analyze risk factors for the development of papillary thyroid carcinoma.Results Compared with the control group,the levels of thyroid hormones and anti-thyroid peroxidase autoantibodies(P＜0.05),as well as the levels of iodine and copper in plasma,were increased in the experimental group(P＜0.05).Logistic regression analysis revealed that female gender,elevated blood iodine,and decreased blood zinc and selenium levels increased the risk of papillary thyroid cancer(P＜0.05).Conclusions Patients with papillary thyroid cancer have higher blood iodine,lower blood zinc and lower selenium levels,compared with healthy individuals.Iodine,zinc,and selenium,these essential trace elements,may have a potential impact on the occurrence and development of papillary thyroid carcinoma.
万方数据
维普
