Clinical Efficacy of Laparoscopic-assisted Gastric Repair in Acute Gastric Perforation and Its Effects on Inflammatory-stress Factors and Gastrointestinal Hormone Levels
Objective To investigate clinical efficacy of laparoscopic-assisted gastric repair in acute gastric perforation and its effects on inflammatory-stress factors and gastrointestinal hormone levels.Methods 62 patients with acute gastric perforation were divided into the observation group(n=31)and the control group(n=31)based on different surgical procedures.The observation group underwent laparoscopic-assisted gastric repair,and the control group received laparotomy.The surgery-related indexes and postoperative gastric power recovery,pain scores(VAS score),and complications were compared in the 2 groups;gastrointestinal hormones[gastrin(GAS),motility(MOT),and somatostatin(SS)],inflammatory factors[hypersensitivity-C protein response(hs-CRP),interleukin-6(IL-6),and procalcitoninogen(PCT)],and the levels of stress factors[dopamine(DA),adrenaline(NE),5-hydroxytryptamine(5-HT)]were observed in the 2 groups.Results In the observation group,hospitalization time,intraoperative bleeding,operation time and incidence of postoperative complications,VAS score,anal exhaust time,defecation time,bowel sound recovery time,hs-CRP level,IL-6 level,PCT level,DA level,NE level,5-HT level were significantly reduced compared with the control group(P＜0.05);postoperative GAS,MOT and SS levels were significantly increased compared with the control group(P＜0.05);the difference in terms of postoperative drain removal time was not statistically significant between the two groups(P＞0.05).Conclusions In the management of acute gastric perforation,laparoscopic-assisted gastric repair can reduce inflammatory stress,relieve pain,improve gastrointestinal function,and promote recovery.
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维普
