Objective To systematically evaluate risk factors for the progression of mild cognitive impairment(MCI)to Alzheimer's disease(AD)so as to provide a reference for early intervention.Methods A computerized search for the literature on risk factors influencing the progression of MCI patients to AD was conducted in 6 major domestic and international databases,and the retrieval time was from the establishment of the database to December 2022.Literature screening and data extraction were performed by 2 researchers individually,and data were analyzed using Stata SE12.0 software.Results A total of 35 articles were included,comprising 10,985 MCI patients,with 13 identified risk factors.Meta-analysis results indicated that the prevalence of AD in MCI patients was 32%,with age[RR=1.07,95%CI(1.02-1.13)],gender[RR=1.50,95%CI(1.33-1.68)],depression[RR=1.23,95%CI(1.02-1.48)],hypertension[RR=1.45,95%CI(1.04-2.03)],diabetes[RR=1.92,95%CI(1.44-2.56)],cerebrovascular disease[RR=1.78,95%CI(1.18-2.69)],and the ApoE gene[RR=1.77,95%CI(1.56-2.01)]identified as significant risk factors for the progression of MCI to AD(P＜0.05).Conclusions MCI patients have a relatively high risk of the progression of MCI to AD,and there are different risk factors.Early screening and intervention should be advisably carried out to reduce the incidence of AD.
万方数据
维普
