Objective To investigate the efficacy of awake prone positioning ventilation in non-intubated patients with hypoxic respiratory failure due to COVID-19.Methods 200 non-intubated patients with hypoxic respiratory failure due to COVID-19 admitted from December 2022 to January 2023 were selected for the study and randomly divided into the control group and the test group,100 patients in each group;the control group was given conventional treatment and care,and the test group was further given awake prone positioning ventilation;oxygenation indexes,hemodynamic indexes,and the occurrence of adverse events during the intervention period were compared between the two groups before the intervention and at 2 h,24 h,and 3 d after the intervention.Results 97 cases in the control group and 98 cases in the study group completed this study.The findings compared at different time points after the intervention showed that the difference in oxygenation indexes of the 2 groups was statistically significant(Pintergroup＜0.001),and the difference in the interaction effect of time and grouping was statistically significant(Pinteraction＜0.001);there were no statistically significant differences in heart rate(Pintergroup=0.312,Ptime=0.125,Pinteraction=0.344),systolic blood pressure(Pintergroup=0.835,Ptime=0.865,P interaction=0.369),and diastolic blood pressure(Pintergroup=0.888,Ptime=0.212,Pinteraction=0.091)between the 2 groups;the difference in the incidence of adverse events was not statistically significant between the 2 groups(P＞0.05).Conclusions Awake prone positioning is safe and feasible in non-intubated patients with hypoxic respiratory failure caused by COVID-19,which can not only promote pulmonary ventilation but also keep hemodynamic stabilization.
维普
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