Weisu Granule Combined with Bismuth-containing Quadruple Therapy in Elderly Patients with Helicobacter Pylori Positive Gastric Ulcer
Objective To investigate clinical effect of Weisu granule combined with bismuth-containing quadruple therapy in the management helicobacter pylori(Hp)positive gastric ulcer among elderly patients.Methods A total of 86 elderly patients with Hp-positive gastric ulcer admitted to Shangrao Central Hospital from July 2022 to October 2023 were selected and divided into a control group and an observation group,using the random number table method,with 43 patients in each group.The control group was given bismuth-containing quadruple therapy,whereas the observation group was administered with Weisu granules on the basis of the control group's treatment,both for a duration of 8 weeks.Clinical efficacy,symptom scores,levels of inflammatory cytokines[interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)],gastric mucosal function[gastrin(GAS),pepsinogenⅠ(PGⅠ),and pepsinogenⅡ(PGⅡ)levels],Hp clearance rate,and adverse reactions were compared between the 2 groups.Results The total effective rate in the observation group was higher than that in the control group(93.35%vs 81.40%,P＜0.05).Compared to the control group,the observation group had lower symptom scores[(2.58±0.30)vs(3.27±0.45)],lower levels of IL-6[(15.23±2.04)pg·mL-1 vs(18.41±2.15)pg·mL-1],CRP[(5.33±1.03)mg·L-1 vs(6.86±1.12)mg·L-1],and TNF-α[(28.68±2.15)pg·mL-1 vs(33.17±2.89)pg·mL-1],and lower levels of GAS[(92.96±5.42)ng·L-1 vs(105.46±8.33)ng·L-1](P＜0.05);the levels of PGⅠand PGⅡ were higher in the observation group than those in the control group(P＜0.05),(132.85±15.16)μg·L-1 vs(103.84±14.50)μg·L-1 and(10.68±1.21)μg·L-1 vs(9.13±0.72)μg·L-1,respectively;Hp clearance rate was higher in the observation group than that in the control group(93.02%vs 76.74%,P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the control group and the observation group[6.98%(3/43)vs 9.30%(4/43)](P＞0.05).Conclusion Weisu granule combined with bismuth-containing quadruple treatment demonstrates positive efficacy in the management of Hp-positive gastric ulcer.This combined regiment can enhance Hp clearance rate,alleviate inflammatory responses,provide protection to gastric mucosa,and facilitate the resolution of symptoms,contributing to safe and effective therapeutic outcomes.
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