An Analysis of Differential Expression Patterns of Cytokines and Lymphocyte Subpopulations in Acute and Chronic Phases of Eczema and Their Association with the Severity of the Disease
Objective To analyze differential expression patterns of cytokines and lymphocyte subpopulations in patients with acute and chronic phases of eczema,as well as to explore their correlation with the severity of the disease.Methods Clinical characteristics,peripheral blood eosinophil counts and levels of cytokines and lymphocyte subsets,and severity index(EASI)scores were retrospectively collected from patients with eczema in acute and chronic phases who were hospitalized at the First Affiliated Hospital of Nanchang University from May 2023 to May 2024.A comparative analysis was conducted to investigate differences in eosinophils,cytokines,lymphocyte subpopulations,and EASI scores between acute and chronic eczema;a correlation analysis was performed to examine the relationship between eosinophils,cytokines,lymphocyte subpopulations,and the severity of acute and chronic eczema.Results There were statistically significant differences in the comparison of eosinophil counts,IL-22 levels,and CD4+T cell counts between patients with acute and chronic eczema(P＜0.05).Correlation analysis indicated a positive correlation between CD4+T cells and EASI scores in acute eczema(r=0.236,P＜0.05).In chronic eczema,there was a positive correlation between eosinophils,IL-5,IL-10,IL-22,and EASI scores(r=0.338,0.267,0.271,0.228,respectively;P＜0.05).Conclusion There are differences in cytokines and lymphocyte subpopulations between acute and chronic phases of eczema,and abnormal indicators can serve as assessment tools for the severity of acute and chronic eczema.
万方数据
维普
