Atherosclerotic cardiovascular disease(ASCVD),characterised by high morbidity and lethality,is a major contributor to the global disease burden.Dyslipidemia,especially low-density lipoprotein cholesterol(LDL-C)abnormality,is one of the major risk factors for ASCVD.It has been found that ASCVD risk still exists in populations with normal LDL-C,and furthermore,it has been shown that lipid subgroups are more accurate than LDL-C in predicting ASCVD risk.Since the discovery of lipid subgroups,researchers have been searching for lipoprotein subfractions with high atherogenic properties that could provide new biomarkers and therapeutic targets for ASCVD.This article provides a review of the nature of lipid subgroups,detection methods,and the correlation with ASCVD,in order to provide a theoretical basis for the clinical predictive value of lipid subgroups.
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