Alternating Locking with Sodium Citrate and Urokinase in Long-term Central Venous Catheter Locking in Hemodialysis Patients
Objective To investigate the impact of alternating use of sodium citrate and urokinase as catheter locking solutions on maintaining long-term central venous catheters in hemodialysis patients.Methods A total of 46 patients with uremia maintained by long-term indwelling catheters for hemodialysis were selected and divided into a control group and an observation group based on different catheter locking solutions,with 23 patients in each group.The control group used heparin sodium for catheter locking,while the observation group used sodium citrate and urokinase to lock catheters alternately.All patients were followed up for 1 year.The incidence of catheter-related infections,catheter malfunction rates,and other complications were compared between the 2 groups.Results During the one-year follow-up,the morning catheter days in the observation group and the control group were 3625 and 3619,respectively.The incidence of catheter-related infections was lower in the observation group than that in the control group(8.69%vs 17.39%,P＜0.05),and the incidence of catheter malfunction was also lower in the observation group than in the control group(2.97%vs 7.24%,P＜0.05).The incidence of subcutaneous bleeding was the same in both groups(4.35%),with no statistically significant difference(P＞0.05).Conclusion Alternating use of sodium citrate and urokinase for long-term central venous catheter locking in hemodialysis patients can positively reduce the incidence of catheter-related bloodstream infections and catheter malfunction.
uremiacentral venous catheterlong termhemodialysissodium citrateurokinasecatheter-related infectioncatheter function
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