Pathogenic Bacteria and Microbial Community Characteristics in Bronchoalveolar Lavage Fluid and Prognosis of Severe Pneumonia:a Correlation Analysis
Objective To investigate the correlation between pathogenic bacteria and microbial community characteristics in bronchoalveolar lavage fluid and the prognosis of severe pneumonia.Methods 80 patients with severe pneumonia admitted to Dexing City People's Hospital from June 2023 to March 2024 were selected as the study subjects.The patients were divided into a death group(n=18)and a survival group(n=62)based on prognosis,followed up for 28 days.Differences in general information,clinical indicators,bronchoalveolar lavage fluid pathogenic bacteria and microbial community were compared between the 2 groups.Results The total hospital stay,ICU stay,Acute Physiology and Chronic Health EvaluationⅡ(APACHEⅡ)score,Clinical Pulmonary Infection score(CPIS),proportion of invasive mechanical ventilation,and comorbidity rate were significantly higher in the death group than in the survival group(P＜0.05).The rates of streptococcus and klebsiella infections among the pathogens in bronchial alveolar lavage fluid,as well as the rates of bacterial and viral infections among the microbiota,were higher in the death group than those in the survival group(P＜0.05).Conclusion These findings indicate that there is a correlation between the type and quantity of pathogenic bacteria and microbial community in bronchoalveolar lavage fluid and the prognosis of patients with severe pneumonia,and that the detection of pathogenic bacteria and microorganisms by bronchoalveolar lavage fluid can contribute to individualized treatment and enhance the outcome of patient care.
bronchoalveolar lavage fluidpathogenic bacteriamicrobial community characteristicssevere pneumoniaprognosis
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