摘要
目的 总结肿瘤患者免疫治疗相关皮肤毒性预防及管理的最佳证据.方法 系统检索各指南及数据库中关于肿瘤患者免疫治疗相关皮肤毒性预防及管理的文献,检索时间为建库至2023年8月1日.对纳入的文献进行质量评价,提取和汇总证据.结果 共纳入14篇文献,包括1篇临床决策、5篇指南、6篇专家共识和2篇系统评价.从免疫治疗相关皮肤毒性的危险因素、预防措施、评估和诊断、发作期护理、非药物干预、监测和随访、健康教育7个方面总结出25条证据.结论 本研究对肿瘤患者免疫治疗相关皮肤毒性预防及管理进行了最佳证据汇总.医护人员在临床实践过程中可结合具体情境选择证据.
Abstract
Objective To systematically review the best evidence for the prevention and management of immunotherapy-related cutaneous toxicity in cancer patients.Methods A systematic literature search was conducted on guidelines and databases for literature related to the prevention and management of immunotherapy-related cutaneous toxicity in cancer patients,with the search period extending from database inception to August 1,2023.The included literature was evaluated for quality,and evidence was extracted and summarized.Results 14 articles were included,comprising 1 clinical decision,5 guidelines,6 expert consensus,and 2 systematic reviews.Evidence was summarized across 7 aspects,including risk factors,preventive measures,assessment and diagnosis,management during episodes,non-pharmacological interventions,monitoring and follow-up,and health education,yielding a total of 25 pieces of evidence.Conclusion This article provides a comprehensive synthesis of the best evidence for the prevention and management of immunotherapy-related cutaneous toxicity in cancer patients.Healthcare professionals can utilize the evidence based on specific contexts in clinical practice.
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