首页|肿瘤患者免疫治疗相关皮肤毒性预防及管理的证据总结

肿瘤患者免疫治疗相关皮肤毒性预防及管理的证据总结

Evidence Summaries for the Prevention and Management of Immunotherapy-related Cutaneous Toxicity in Cancer Patients

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目的 总结肿瘤患者免疫治疗相关皮肤毒性预防及管理的最佳证据.方法 系统检索各指南及数据库中关于肿瘤患者免疫治疗相关皮肤毒性预防及管理的文献,检索时间为建库至2023年8月1日.对纳入的文献进行质量评价,提取和汇总证据.结果 共纳入14篇文献,包括1篇临床决策、5篇指南、6篇专家共识和2篇系统评价.从免疫治疗相关皮肤毒性的危险因素、预防措施、评估和诊断、发作期护理、非药物干预、监测和随访、健康教育7个方面总结出25条证据.结论 本研究对肿瘤患者免疫治疗相关皮肤毒性预防及管理进行了最佳证据汇总.医护人员在临床实践过程中可结合具体情境选择证据.
Objective To systematically review the best evidence for the prevention and management of immunotherapy-related cutaneous toxicity in cancer patients.Methods A systematic literature search was conducted on guidelines and databases for literature related to the prevention and management of immunotherapy-related cutaneous toxicity in cancer patients,with the search period extending from database inception to August 1,2023.The included literature was evaluated for quality,and evidence was extracted and summarized.Results 14 articles were included,comprising 1 clinical decision,5 guidelines,6 expert consensus,and 2 systematic reviews.Evidence was summarized across 7 aspects,including risk factors,preventive measures,assessment and diagnosis,management during episodes,non-pharmacological interventions,monitoring and follow-up,and health education,yielding a total of 25 pieces of evidence.Conclusion This article provides a comprehensive synthesis of the best evidence for the prevention and management of immunotherapy-related cutaneous toxicity in cancer patients.Healthcare professionals can utilize the evidence based on specific contexts in clinical practice.

tumorimmunotherapycutaneous toxicityevidence summariesevidence-based medicine

王静怡、桂芊、刘蓓佳、高奇、刘茂、向明芳

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电子科技大学医学院护理系,成都 610051

电子科技大学医学院附属肿瘤医院、四川省肿瘤医院危重医学中心,成都 610041

肿瘤 免疫治疗 皮肤毒性 证据总结 循证医学

2024

实用临床医学
南昌大学

实用临床医学

影响因子:0.818
ISSN:1009-8194
年,卷(期):2024.25(6)