老年空腹血糖受损62例进展研究
Study on the progression of impaired fasting glucose in 62 elderly cases
尹秋生 1姚依群 1曹少军 1周书明1
作者信息
- 1. 100700北京市,中国人民解放军北京军区总医院干一科
- 折叠
摘要
目的 分析老年空腹血糖受损者(IFG)8年间进展情况. 方法 于2002年5～6月对我区离退休老干部中IFG行口服75 g葡萄糖试验(OGTT),选取单纯空腹血糖受损者(I-IFG) 62例,依据2003年美国糖尿病学会IFG诊断标准,将空腹血糖(FPG)为5.6 ～ 6.09 mmol/L的受损者分为新增IFG组(A组),空腹血糖为6.1 ～6.99mmol/L的受损者分为原IFG组(B组),定期随访8年. 结果 基线时2组IFG者的血压、血脂、体质量指数(BMI)等临床指标差异均无统计学意义(P＞0.05).至随访结束时,A组进展为糖尿病(DM)的比率为20.59％,B组IFG进展为DM的比率为46.43％,是A组的2.25倍,差异有统计学意义(P＜0.05)；2组IFG逆转为糖耐量正常(NGT)、仍保持I-IFG以及进展为空腹血糖受损合并糖耐量受损(IFG/IGT)者的比率差异均无统计学意义(P＞0.05).全部IFG进展为DM的比率是32.25％,逆转为NGT的比率是14.52％,仍维持在I-IFG或IFG/IGT状态的比率是53.23％. 结论 IFG诊断标准下调后,IFG患病率明显上升,但新增IFG进展为DM的风险明显低于原IFG.
Abstract
Objective To analyse the progression of impaired fasting glucose (IFG) in the elderly after a follow-up of eight years. Methods The retired military officers with IFG underwent an oral glucose tolerance test from May to June in 2002,and 62 cases with I-IFG were recruited. According to the new IFG diagnosis criterion of ADA in 2003 year, 62 cases with I-IFG were divided into added IFG group(FPG:5. 6 -6. 09 mmol/L) and original IFG group(FPG;6. 1 -6. 99 mmol/L). All patients were followed up for eight years. Results The levels of TC, LDL-C, HDL-C, TG, blood pressure, and BMI showed no significant differences between added IFG group and original IFG groups ( P > 0. 05 ) at baseline. At the endpoint of follow-up, 20.59% of the cases progressed to diabetes in added IFG group, compared with 46. 43% in original IFG group (P < 0. 05). But there were no significant differences in the rate of cases converting to NGT, or still keeping I-IFG or IFG/IGT between two groups(P > 0. 05). Of all the cases of IFG, 32. 25% progressed to diabetes,14. 52% reverting to NGT, 53. 23% presenting with I-IFG or IFG combined with IGT. Conclusions The prevalence rate of IFG increased significantly according to the new criteria of IFG. The progression rate from added IFG to diabetes is lower than that of original IFG.
关键词
老年人/空腹血糖受损/糖尿病Key words
aged/impaired fasting glucose/diabetes mellitus引用本文复制引用
出版年
2012
NETL
NSTL
维普
万方数据