Objective To assess the nutritional state and the risk factors of malnutrition of elderly inpatients with dementia and to explore its relationship with clinical outcomes.Methods A total of 103 inpatients with Alzheimer's disease aged 65 and over were enrolled.Routine examinations of the blood were detected and the NRS2002,the MMSE,the BI index,and the Charlson Comordility Index (CCI) were evaluated in all subjects.Comorbidities,death,and nutritional supports were recorded until discharges of the subjects or until the endpoint of 30 days.Results There were 50 (48.5%) subjects with nutritional risks,44 (42.7%) with malnutrition.34 (33.0%) subjects suffered infective comorbidities,9 (8.7%) suffered non-infective comorbidities,1 died during the study period.Average CCI of subjects with risk of malnutrition was statistically higher and BI index was statistically lower than that without malnutrition (P<0.05).The rate of suffering comorbidities and the rate of malnutrition in subjects with risk of malnutrition was statistically higher than those without (P<0.05).A model of logistic regression analysis showed that both malnutrition and CCI score were significant variables which influenced the clinical outcomes.Conclusions The rate of nutritional risks and malnutrition is high in elderly inpatients with dementia.Both the nutritional risks and the chronic physical comorbidities deteriorate the clinical outcomes significantly.