Efficacy analysis of melasma treatment using Q-switched 1064 nm Nd:YAG laser combined with glycolic acid
Objective To explore the clinical efficacy and safety of Q-switched 1064 nm Nd:YAG laser combined with or stan-dalone treatment of glycolic acid for melasma.Methods From January 2017 to December 2022,84 patients with melasma who visited the Department of Plastic Surgery of Beijing Tsinghua Chang Gung Hospital(School of Clinical Medicine,Tsinghua University)were divided into observation and control groups according to treatment methods.The control group(44 patients)was given glycolic acid treatment alone(once every four weeks,a total of 10 treatments,for two courses).The observation group(40 patients)was treated with glycolic acid com-bined with Q-switched laser;laser treatment was interspersed during the treatment period of glycolic acid according to the patient's skin condition(once every four weeks,four treatments for one course).The area and severity of melasma(melasma area severity index,MASI)were statistically analyzed before treatment and six months after all treatments,and the occurrence of adverse reactions was recorded.Results After treatment,the MASI scores of both groups of patients decreased,and the decrease rate of the MASI score in the observation group(41.23±12.34)%was higher than that in the control group(26.19±7.84)%,the difference was statistically significant(P<0.05);the clinical treatment effective rate(72.5%and 45.45%)and patient satisfaction rate(65%and 40.90%)of the observation group compared with the control group were statistically significant(P<0.05).Adverse reactions such as sting,itch,and scab that occurred after treatment disap-peared after symptomatic treatment,and no serious adverse reactions leading to treatment discontinuation occurred.Conclusion The use of glycolic acid combined with Q-switched 1064 nm Nd:YAG laser and the single application of glycolic acid have definite therapeutic ef-fects on facial melasma,but the combined treatment has better effects,higher safety,and can obtain higher satisfaction.It is worth promot-ing in clinical practice.
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