Efficacy of botulinum toxin type A combined with red and blue light in the treatment of mild to moderate acne
Objective To investigate the efficacy of intra-dermal administration of botulinum toxin type A combined with red and blue light in the treatment of mild to moderate acne and the effect on proteins related to skin barrier function in patients.Methods There were 60 patients with mild to moderate acne were randomly divided into two groups,with 30 cases in each group.The control group was treated with adapalene gel combined with red and blue light,and the experimental group was treated with botulinum toxin A intradermal administration combined with red and blue light.The clinical efficacy,adverse reaction rate,satisfaction rate,and acne comprehensive grading system(GAGS)score,acne scar weighted score(ECCA),content of mucin,secretion rate of sebaceous gland,expression of toll-like receptor 2(TLR2)and TLR4 before and after treatment were compared between the two groups.Results The total effective rate(96.67%,73.33%)in the experimental group were higher than those in the control group(P<0.05),while there was no significant difference in the in-cidence of adverse reactions between the two groups(P>0.05).The GAGS score,ECCA score,mucin content,sebaceous gland secretion rate,and TLR2 and TLR4 expression in the experimental group were lower than those in the control group 1 month and 3 months after treatment(P<0.05).Conclusion Intradermal administration of botulinum toxin type A combined with red and blue light therapy for the treatment of mild to moderate acne can effectively reduce inflammatory reactions,reduce sebum secretion,improve skin barrier function and scarring,with significant efficacy,high safety,and high patient satisfaction.
Botulinum toxin type ASkin barrier functionRed and blue light irradiationModerate-to-severe acneToll-like re-ceptors
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