The changes of serum ICAM-1,IL-10 and TNF-α levels in burn patients and their relationship with wound healing degree
Objective To analyze the changes of serum intercellular adhesion molecule-1(ICAM-1),interleukin-10(IL-10)and tumor necrosis factor-α(TNF-α)levels in burn patients and the relationship between them and the degree of wound healing.Methods A total of 120 burn patients admitted to Department of Burn,Zhangjiakou First Hospital,from January 2020 to February 2023 were selected,and the serum levels of ICAM-1,IL-10 and TNF-α at 1,28 days after admission were compared.According to the median levels of serum ICAM-1,IL-10 and TNF-α,the patients were divided into high expression group and low expression group,and the degree of wound healing between the groups was compared.Pearson correlation was used to analyze the correlation between the degree of wound healing and serum ICAM-1,IL-10 and TNF-α in burn patients.According to the wound healing quality of burn patients,the predictive value of serum ICAM-1,IL-10 and TNF-α on wound healing quality of burn patients was evaluated by ROC curve.Results On the 1,28 day after admission,the serum levels of ICAM-1,IL-10 and TNF-α in burn patients were significantly different(P＜0.05).The wound healing degree of ICAM-1 high expression group was significantly lower than that of ICAM-1 low expression group(P＜0.05).The wound healing degree of high IL-10 expression group was significantly lower than that of low IL-10 expression group(P＜0.05).The wound healing degree of high TNF-α expression group was significantly lower than that of low TNF-α expression group(P＜0.05).Pearson correlation analysis showed that the degree of wound healing in burn patients was negatively correlated with serum ICAM-1,IL-10 and TNF-α(P＜0.05).ROC curve results showed that the area under the curve of serum ICAM-1,IL-10 and TNF-α on the 28 day after admission was greater than that of serum ICAM-1,IL-10 and TNF-α on the 1 day after admission,and the area under the curve of combined detection of the three was greater than that of any single detection.These results indicated that the combined detection of the three methods could be used as an effective indicator to predict the quality of wound healing in burn patients,and the predictive value of serum ICAM-1,IL-10 and TNF-α after treatment was higher.Conclusion Serum ICAM-1,IL-10 and TNF-α were negatively correlated with the degree of wound healing in burn patients,and the combined detection of the three could provide a reference for clinical prediction of wound healing quality.
BurnSerum intercellular adhesion molecule-1Interleukin-10Tumor necrosis factor-αDegree of wound healing
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