Efficacy of bFGF gel combined with ultra-pulsed CO2 fractional laser on facial acne depressed scars and influence on skin lesion status
Objective To study the efficacy of recombinant bovine basic fibroblast growth factor(bFGF)gel combined with ul-tra-pulsed CO2 fractional laser in the treatment of facial acne depressed scars.Methods Sixty patients with facial acne depressed scars who were treated in department of plastic surgery from February 2022 to February 2023 were selected and randomly divided into gel+CO2 group(ultra-pulsed CO2 fractional laser followed by bFGF gel smear treatment,n=30)and CO2 group(ultra-pulsed CO2 fractional laser,n=30),and both groups were followed up for 3 months after the end of treatment.The clinical efficacy,symptom improvement status,skin physiological condition[water content of stratum corneum,transepidermal water loss(TEWL),itching score,skin texture value]and scar improvement[Vancouver Scar Scale(VSS)score,echelled'evaluationclinique descicatricesd'acne(ECCA),global aesthetic improvement scale(GAIS)]before and after treatment were compared between both groups.The adverse reaction rate and follow-up aesthetic satisfaction were counted in the two groups.Results The total clinical effective rate in gel+CO2 group was 96.67％,which was significantly higher than 80.00％in CO2 group(P＜0.05).After laser treatment,the symptom duration and wound healing time in gel+CO2 group were shorter than those in CO2 group(P＜0.05).After 1 month and 3 months of treatment,the water content of stratum corneum and skin texture value were higher in both groups than those before treatment(P＜0.05),and the indicators were higher in gel+CO2 group than those in CO2 group(P＜0.05),and the TEWL and skin itching degree were decreased in both groups(P＜0.05),and the indicators in gel+CO2 group were lower than those in CO2 group(P＜0.05).The ECCA score in both groups was gradually reduced after 1 month and 3 months of treatment(P＜0.05),and the score in gel+CO2 group was lower than that in CO2 group(P＜0.05),and the GAIS score in both groups were higher than those before treatment(P＜0.05),and the scores in gel+CO2 group were significantly higher than those in CO2 group(P＜0.05).The total adverse reaction rate in gel+CO2 group(6.67％)was significantly lower than that in CO2 group(26.67％)(P＜0.05).The satisfaction in gel+CO2 group(93.33％)was significantly higher than 73.33％in CO2 group(P＜0.05).Conclusion bFGF gel combined with ultra-pulsed CO2 fractional laser has a definite efficacy in the treatment of facial acne depressed scars,and it can significantly improve the skin physio-logical status and promote the repair of damaged skin,it has few adverse reactions and high aesthetic satisfaction.
Depressed scarsAcnebFGF gelUltra-pulsed CO2 fractional laser
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