In education and teaching,university laboratories have a dual function of carrying teaching and research,and providing social services.The safety management of university laboratories has also attracted people's attention.Therefore,this article conducts research and analysis on the"6S Management"and"dual prevention mechanism"in the safety management of university laboratories.By focusing on the management of 6S and introducing the"dual prevention mechanism"approach,it can better achieve on-site operations,graded management and control,and safety hazard investigation in university laboratories,thereby avoiding physical injuries to students caused by the use of physical,chemical and other experimental equipment in university laboratory teaching.Based on the research of"6S"and dual prevention mechanism in laboratory safety management,the goal of comprehensively improving laboratory safety management level can be achieved through measures such as optimizing laboratory equipment and establishing effective emergency prevention plans,laying a solid foundation for ensuring the safe operation of university laboratories and protecting personnel and equipment safety.