Objective Exploring the influence of crystal form of ceftriaxone sodium on the quality of ceftriaxone sodium for injection products.Methods Analyze the relationship and reasons between crystal form and product quality by comparing the changes in polymer content of different crystal form products after long-term and accelerated testing.Results There are differences in the quality stability of different crystal forms of ceftriaxone sodium products.Conclusion Production enterprises should pay attention to the production process and choose the optimal crystal form to improve product quality.