摘要
目的 通过基因测序技术对多发性骨髓瘤(MM)的早期诊断和预后检测进行评估.方法 研究纳入 2020年 5 月至 2024 年 5 月期间收治的 68 例MM患者,并将其随机分为观察组(34 例)和对照组(34 例).观察组患者接受基因测序相关的早期诊断和预后评估,对照组则采用传统诊断方法.结果 在早期诊断准确率方面,观察组诊断正确和错误的数量分别为 31 例和 3 例,诊断准确率为 91.2%;对照组诊断正确和错误的数量分别为 23 例和 11例,诊断准确率为 67.62%,观察组更高,P＜0.05.在预后评估对比方面,观察组ISS分期Ⅰ、ISS分期Ⅱ、ISS分期Ⅲ、高危突变检测数量分别为 10 例、15 例、9 例、12 例,预后评估准确率为 85.3%;对照组ISS分期Ⅰ、ISS分期Ⅱ、ISS分期Ⅲ、高危突变检测数量分别为 8 例、13 例、13 例、8 例,预后评估准确率为 67.6%,观察组预后评估准确率明显高于对照组;观察组总生存率、无进展生存率分别为 94.1%、70.6%,对照组总生存率、无进展生存率分别为 82.4%、52.9%,相比来说观察组总生存率、无进展生存率均更高,P＜0.05.结论 基因测序技术有助于MM的早期发现和个性化治疗方案的制定,提升患者的生存率和生活质量,在临床实践中具备应用和推广的价值.
Abstract
Objective To evaluate the early diagnosis and prognosis of multiple myeloma(MM)by gene sequencing technology.Methods 68 patients with MM admitted from May 2020 to May 2024 were randomly divided into observation group(34 cases)and control group(34 cases).Patients in the observation group received early diagnosis and prognosis assessment related to gene sequencing,while those in the control group received traditional diagnosis methods.Results In the early diagnosis accuracy,the number of correct and wrong diagnoses in the observation group was 31 cases and 3 cases,respectively,and the diagnosis accuracy was 91.2%.The number of correct and wrong diagnoses in control group was 23 cases and 11 cases,respectively,the diagnostic accuracy was 67.62%,and the observation group was higher(P<0.05).In the observation group,the number of ISS stageⅠ,ISS Stage Ⅱ,ISS Stage Ⅲ and high-risk mutation detection were 10 cases,15 cases,9 cases and 12 cases,respectively,and the accuracy of prognosis assessment was 85.3%.In the control group,there were 8 cases of ISS stageⅠ,13 cases of ISS stage Ⅱ,13 cases of ISS stage Ⅲ and 8 cases of high-risk mutation detection,respectively.The accuracy of prognosis assessment was 67.6%,and the accuracy of prognosis assessment in the observation group was significantly higher than that in the control group.The overall survival rate and progression-free survival rate were 94.1%and 70.6%in the observation group,and 82.4%and 52.9%in the control group,respectively,which were higher in the observation group(P<0.05).Conclusion Gene sequencing technology is helpful to the early detection of MM and the formulation of personalized treatment plan,improve the survival rate and quality of life of patients,and has the value of application and promotion in clinical practice.
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