Objective In order to ensure the quality control of enterprise production products and improve detection efficiency,a high-performance liquid chromatography method for Benzyl Propionate Oxadiazon Granules is established.Methods The HPLC method was used to separate and determine the contents of Benzyl Propionate Oxadiazon Granules which contained the active ingredients mentioned above.In the method,the column ZORBAX Eclipse Plus C18(4.6 mm×50 mm,1.8 μm,600 Bar)was used and the mixture of acetonitrile,isopropanol and 0.05%phosphoric acid solution was used as the mobile phase,and 245 nm was the selected wavelength in the determination.Results It has been found that bensulfuron methyl,pretilachlor,and oxadiazon not only have high chromatographic peak purity under this analytical method,but also have a good linear relationship.The peak purity of bensulfuron methyl in this product is 992,with a recovery rate of 98.82%.The peak purity of pretilachlor is 993.3,with a recovery rate of 99.88%.The peak purity of oxadiazon is 999.3,and the recovery rate is 99.22%.Conclusion This chromatographic method is stable and suitable for quality control analysis of this product.