Objective To evaluate the advantage clinical value of cold digestion method and national standard method in the determination of serum iodine.Methods The DAT-500 iodine detector of Changsha Seclude and the cold digested serum iodine detection reagent(patent:CN113340888A reagent kit and detection method for serum quantitative detection)were used to compare with the national standard Determination of Iodine in Serum by Catalytic Spectrophotometry.Results From 0 to 300 μg/L iodine content range,the absolute value of correlation coefficient of standard curve of 5 batches exceeded 0.9995,the detection limit was 2.1 μg/L;the recovery rate of 9 serum samples with different concentrations was 94.6%～108.8%;6 batches of 3 serum samples with different concentrations were tested,the RSD was 3.41%～4.01%,and the recovery rate was 94.6%～108.8%;there was no statistical significance between 20 serum samples and national standard method(t=-1.660,P=0.113>0.05).Conclusion Cold digestion method has the advantages of high accuracy and accuracy,simple operation,short time consuming,low demand for temperature control,easy storage and transportation at room temperature.
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