首页|JunB condensation attenuates vascular endothelial damage under hyperglycemic condition

JunB condensation attenuates vascular endothelial damage under hyperglycemic condition

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Endothelial damage is the initial and crucial factor in the occurrence and development of vascular complications in diabetic patients,contributing to morbidity and mortality.Although hyperglycemia has been identified as a damaging effector,the detailed mechanisms remain elusive.In this study,identified by ATAC-seq and RNA-seq,JunB reverses the inhibition of proliferation and the promotion of apoptosis in human umbilical vein endothelial cells treated with high glucose,mainly through the cell cycle and p53 signaling pathways.Furthermore,JunB undergoes phase separation in the nucleus and in vitro,mediated by its intrinsic disordered region and DNA-binding domain.Nuclear localization and condensation behaviors are required for JunB-mediated proliferation and apoptosis.Thus,our study uncovers the roles of JunB and its coacervation in repairing vascular endothelial damage caused by high glucose,elucidating the involvement of phase separation in diabetes and diabetic endothelial dysfunction.

hyperglycemiaJunBphase separationendothelial damage

Xuxia Ren、Zexu Cui、Qiaoqiao Zhang、Zhiguang Su、Wei Xu、Jinhui Wu、Hao Jiang

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Laboratory for Aging and Cancer Research,Frontiers Science Center Disease-related Molecular Network,State Key Laboratory of Respiratory Health and Multimorbidity and National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University,Chengdu 610041,China

Key Laboratory of Gene Engineering of the Ministry of Education,State Key Laboratory of Biocontrol,School of Life Sciences,Sun Yat-sen University,Guangzhou 510275,China

Molecular Medicine Research Center,West China Hospital,Sichuan University,Chengdu 610041,China

Center of Geriatrics and Gerontology,National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University,Chengdu 610041,China

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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Key Research and Development Program of ChinaNational Key Research and Development Program of ChinaSichuan Science and Technology Program,the Central Government Guides Local Science and Technology Development ProjectsSichuan Science and Technology ProgramScience and Technology Department of Tibet,the Central Government Guides Local Science and Technology Development Projects1.3.5 Project for Disciplines of Excellence1.3.5 Project for Disciplines of Excellence1.3.5 Project for Disciplines of ExcellenceProject of Max Cynader Academy of Brain Workstation,WCHSCUNational Clinical Research Center for GeriatricsNational Clinical Research Center for GeriatricsNational Clinical Research Center for Geriatrics

32090043317715052017YFC08401012018YFA01083022022ZYD00782023YFQ0008XZ202102YD0026CZYYC20001ZYGD20010ZY2017201HXYS19005Z20191011Z20201009Z2023YY003

2023

10.1093/jmcb/mjad072

分子细胞生物学报(英文版)
中国科学院上海生命科学研究院,生物化学与细胞生物学研究所,中国细胞生物学学会

分子细胞生物学报(英文版)

CSTPCDCSCD
影响因子：0.595
ISSN：1673-520X
年,卷(期)：2023.(12)
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