首页|生物信息学融入中药药理学实验教学设计的探索——以酸枣仁汤为例

生物信息学融入中药药理学实验教学设计的探索——以酸枣仁汤为例

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以酸枣仁汤为例,将生物信息学融入实验教学设计与实践,实现了理论教学与实验教学的双融合.生物信息学多靶点、多途径的协同调控与中医药的"整体观念"相契合,而数据可视化帮助学生直观"看到"并理解中药复方的作用机制和科学内涵.将酸枣仁汤"异病同治"失眠和阿尔茨海默病的实验划分成3个教学模块,即基础生物信息实验、异病同治实验、机制探索实验,围绕预习探索、模拟实验和团队协作能力进行系统训练,引导学生自主设计并完善验证性实验.通过线上操作、线下考核、课程汇报等方式优化实验教学模式,全方位提升学生对关键知识的理解能力、应用能力和创新能力.
Exploration of Integrating Bioinformatics into the Experimental Teaching Design of Traditional Chinese Medicine Pharmacology—A Case Study of Suanzaoren Decoction
Bioinformatics is integrated into the design and practice of experimental teaching by taking suanzaoren decoction as an example,which realizes the double integrations of theoretical teaching and experimental teaching.The synergistic effect of multiple targets and pathways of bioinformatics is compatible with the"holistic concept"of traditional Chinese medicine,and the data visualization helps students to intuitively"see"and understand the mechanism and scientific connotation of traditional Chinese medicine compound.The experiment of"different disease treatment"of insomnia and Alzheimer's disease with suanzaoren decoction is divided into three teaching modules,i.e.,basic bioinformatics experiment,experiment of different disease treatment,and experiment of exploring mechanism,and systematic training is provided around the abilities of pre-study exploration,simulation experiment and teamwork,which guides students to independently design and improve the validation experiments.The experimental teaching mode is optimized through online operation,offline assessment,and course reporting to enhance students'understanding of key knowledge,application ability and innovation ability in an all-round way.

bioinformaticstraditional Chinese medicine pharmacologysuanzaoren decoctionheterogeneous disease treatment

尹超、张美娅、王平、丁莉、游秋云、吴和珍

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湖北中医药大学药学院,武汉 430065

湖北中医药大学老年脑健康中医药防护技术与新产品研发教育部工程研究中心,武汉 430065

生物信息学 中药药理学 酸枣仁汤 异病同治

国家自然科学基金湖北省高等学校实验室研究项目

81473560HBSY2022-039

2024

实验室研究与探索
上海交通大学

实验室研究与探索

CSTPCD北大核心
影响因子:1.69
ISSN:1006-7167
年,卷(期):2024.43(5)
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