辣椒辣素在神经病理性疼痛方面的作用机制及应用研究进展
Mechanism and application of capsaicin in neuropathic pain:a literature review
吕传宝 1董英伟2
作者信息
- 1. 广州中医药大学附属第一医院麻醉科,广州市 510000
- 2. 哈尔滨医科大学附属第一医院麻醉科,哈尔滨市 150000
- 折叠
摘要
辣椒辣素是从红辣椒里提取的镇痛物质,其单次腹腔注射镇痛作用时间长达半年(新生鼠)至1年(成熟大鼠),近年来引起广泛关注,成为研究热点.大量临床研究表明,辣椒辣素可以减轻神经病理性疼痛,使患者在行走、工作和睡眠方面均得到改善.因此,辣椒辣素有潜力成为治疗神经病理性疼痛的一线或二线药物.
Abstract
Capsaicin is an analgesic substance extracted from red pepper.The analgesic effect of capsaicin can last half a year(newborn rats)to one year(mature rats)by single intraperitoneal injection.In recent years,capsaicin has attracted wide attention and become a research hotspot.Many clinical studies have shown that capsaicin can relieve neuropathic pain and improve patients'walking,work and sleep.Capsaicin has great potential to become a first-or second-line medicine for the treatment of neuropathic pain.
关键词
神经痛/辣椒辣素/香草酸瞬时受体亚型1/镇痛Key words
Neuralgia/Capsaicin/Transient receptor potential vanilloid-1/Analgesia引用本文复制引用
出版年
2024
NETL
NSTL
万方数据