线粒体糖代谢重编程在神经病理性疼痛中的作用机制研究进展
Research progress on mechanism of mitochondrial glucose metabolism reprogramming in neuropathic pain:a literature review
沈慧慧 1徐建红 1郁丽娜1
作者信息
- 1. 浙江大学医学院附属第四医院麻醉科,浙江省金华市 322000
- 折叠
摘要
越来越多的研究表明神经系统相关免疫细胞在感觉神经系统损害时发生糖代谢重编程,主要通过糖酵解产生能量,并导致乳酸、琥珀酸、柠檬酸等代谢产物的堆积.同时,这些代谢产物通过其促炎作用,促进神经病理性疼痛(NP)的发展.本文旨探究在神经系统中糖代谢重编程及其相关代谢产物在NP的发生发展机制中的作用,以求为NP的治疗方向拓宽思路.
Abstract
More and more studies have shown that the neuron-inflammatory is related to pain sensitization.Under inflammatory conditions,the immune cells in nerve system undergo metabolism reprogramming,glycolysis become the mainly energy resource,leading to the accumulation of lactic acid,succinic acid,citric acid and other metabolites.At the same time,these metabolites have pro-inflammatory effects,and play a positive role in the development of pain.This review summarized the role of glucose metabolism reprogramming and its related metabolites in the pathogenesis of neuropathic pain(NP)under the stimulation of chronic inflammation,to broaden the thinking for the treatment of NP.
关键词
神经痛/小神经胶质细胞/神经炎/糖代谢重编程Key words
Neuralgia/Microglia/Neuritis/Glucose metabolism reprogramming引用本文复制引用
出版年
2024
NETL
NSTL
万方数据