Influencing Factors of Mmune Thrombocytopenic Purpuras in Elderly Patients with Advanced Non-Small Cell Lung Cancer after Carrilizumab Treatment
Objective To analyze the influencing factors of mmune thrombocytopenic purpuras(ITP)in elderly patients with advanced non-small cell lung cancer(NSCLC)after carrilizumab treatment.Methods A total of 89 elderly patients with advanced NSCLC receiving carrilizumab treatment from March 2020 to July 2023 in First Hospital of Qinhuangdao were retrospectively selected as the study objects.According to the occurrence of ITP,the patients were divided into the ITP group(n=1 8)and the non-ITP group(n=71).The clinical data of the patients were collected,and multivariate Logistic regression analysis was used to investigate the influencing factors of ITP in elderly patients with advanced NSCLC after carrilizumab treatment.Results There were significant differences in age,proportion of patients with autoimmune disease history,interleukin-6(IL-6),tumor necrosis factor α(TNF-α),C-reactive protein(CRP),basophil count(BA),platelet count(PLT),soluble programmed death cell protein 1(sPD-1)and soluble programmed death cell protein 1 ligand(sPD-L1)between the two groups(P＜0.05).Multivariate Logistic regression analysis showed that,autoimmune disease history[OR=3.187,95％CI(1.100-9.236)],PLT[OR=0.930,95％CI(0.874-0.989)],sPD-1[OR=1.264,95％CI(1.085-1.472)]and sPD-L1[OR=1.290,95％CI(1.057-1.575)]were independent influencing factors for ITP in elderly patients with advanced NSCLC after carrilizumab treatment(P＜0.05).Conclusion Autoimmune disease history,PLT,sPD-1 and sPD-L1 are independent influencing factors for ITP in elderly patients with advanced NSCLC after carrellizumab treatment.
Carcinoma,non-small-cell lungPurpura,thrombocytopenic,idiopathicElderlyCarrilizumabRoot cause analysis
万方数据
维普
