Influencing Factors of Cognition Disorders in Patients with Aneurysmal Subarachnoid Hemorrhage after Interventional Intravascular Embolization and Construction of Nomogram Model for Predicting Its Risk
Objective To investigate the influencing factors of cognition disorders(CD)in patients with aneurysmal subarachnoid hemorrhage(aSAH)after interventional intravascular embolization and construct its risk prediction nomogram model.Methods A total of 192 patients with aSAH admitted to Huai'an Second People's Hospital from June 2021 to December 2023 were selected as the study objects,and they were divided into the CD group[Montreal Cognitive Assessment Scale(MoCA)score＜26]with 72 cases and the non-CD group(MoCA score ≥ 26)with 120 cases according to the MoCA score at 3 months after interventional intravascular embolization.Clinical data of the patients were collected.Multivariate Logistic regression analysis was used to analyze the influencing factors of CD in patients with aSAH after interventional intravascular embolization.R software was used to construct the nomogram model for predicting the risk of CD in patients with aSAH after interventional intravascular embolization,and ROC curve was drawn to analyze the discrimination of the nomogram model for predicting CD in patients with aSAH after interventional intravascular embolization,and Hosmer-Lemeshow goodness of fit test was used to analyze the fitting degree of the nomogram model.Results There were significant differences in the time from onset to operation,incidence of cerebral infarction within 3 days after operation,Fisher grade and levels of neuronspecific enolase(NSE),S100 calcium-binding protein β(S100[3),and hypersensitive C-reactive protein(hs-CRP)between the two groups(P＜0.05).Multivariate Logistic regression analysis showed that,the time from onset to operation[OR=1.989,95％CI(1.281-3.089)],incidence of cerebral infarction within 3 days after operation[OR=2.361,95％CI(1.413-3.946)],NSE[OR=2.683,95％CI(1.781-4.042)],S100 β[OR=1.180,95％CI(1.028-1.354)],and hs-CRP[OR=4.320,95％CI(2.616-7.135)]were independent influencing factors of CD in patients with aSAH after interventional intravascular embolization(P＜0.05).Based on the results of multivariate Logistic regression analysis,the nomogram model for predicting the risk of CD in patients with aSAH after interventional intravascular embolization was constructed.ROC curve analysis showed that,the area under curve(AUC)of the nomogram model for predicting CD in patients with aSAH after interventional intravascular embolization was 0.885[95％CI(0.839-0.930)].Hosmer-Lemeshow goodness of fit test showed that,the nomogram model fitted well(x 2=8.803,P=0.367).Conclusion The time from onset to operation,incidence of cerebral infarction within 3 days after operation,NSE,S100,and hs-CRP are independent influencing factors of CD in patients with aSAH after interventional intravascular embolization,the nomogram model constructed based on the above influencing factors has a certain predictive value for CD in patients with aSAH after interventional intravascular embolization.
Subarachnoid hemorrhageCognition disordersInterventional intravascular embolizationRoot cause analysisNomogram model
万方数据
维普
