Causal Relationship between Frailty and Risk of Epilepsy:a Mendelian Randomization Analysis
Objective To explore the causal relationship between frailty and risk of epilepsy by mendelian randomization(MR)analysis.Methods Genome-wide association study(GWAS)data for frailty index were obtained from the Gwas Catalog database,which included 175 226 patients with 7 589 717 single nucleotide polymorphisms(SNPs).GWAS data for epilepsy were obtained from the Finn Gen database,which included 6 260 epilepsy cases and 176 107 healthy controls with 16 380 349 SNPs.Inverse variance weighted(IVW)was used to explore the relationship between frailty and risk of epilepsy.MR-Egger regression,weighted median estimator,and weighted mode method analysis were used as complementary methods for IVW.Cochran's Q test and funnel plot were used to analyze whether there was statistical heterogeneity between SNPs.The intercept term of MR-Egger regression was used to analyze the horizontal pleiotropy of SNPs.The leave-one-out method was used to analyze the impact of a single SNP on the MR analysis results.Results IVW analysis showed a positive relationship between frailty and risk of epilepsy[OR=1.584,95％CI(1.086-2.312)].MR-Egger regression and weighted mode method analysis showed that there was no causal relationship between frailty and risk of epilepsy(P＞0.05),but their β-values were in the same direction as the β-value of IVW;and weighted median method analysis showed that there was a positive relationship between frailty and risk of epilepsy[OR=1.642,95％CI(1.036-2.603)].Cochran's Q test and funnel plot analysis showed that there was no statistical heterogeneity between SNPs strongly correlated with frailty index(P＞0.05).The intercept term of MR-Egger regression method showed that there was no horizontal pleiotropy of SNPs strongly correlated with the frailty index(P=0.987).The leave-one-out method analysis showed that after excluding individual SNPs one by one,the results of IVW analysis showed that no significant change.Conclusion There is a positive causal relationship between frailty and risk of epilepsy.
万方数据
维普
