Composition and Drug Resistance of Respiratory Tract Pathogens in Patients with Obstructive Sleep Apnea Hypopnea Syndrome Complicated with Pneumonia
Objective To analyze the composition and drug resistance of respiratory tract pathogens in patients with obstructive sleep apnea hypopnea syndrome(OSAHS)complicated with pneumonia.Methods A total of 312 patients with OSAHS complicated with pneumonia who were hospitalized in the Department of Respiratory Medicine of Nantong First People's Hospital from November 2022 to May 2023 were selected as the study subjects.Sputum samples of patients were collected for identification of respiratory pathogens and analysis of drug resistance of main respiratory pathogens.Results A total of 123 respiratory pathogens were cultured form 312 patients with OSAHS complicated with pneumonia,and the positive rate of culture was 39.4％.A total of 126 strains of respiratory pathogens were cultured,including 59 strains(46.8％)of Gram-positive bacteria(including 33 strains of Streptococcus pneumoniae and 26 strains of Staphylococcus aureus)and 67 strains(53.2％)of Gram-negative bacteria(including 39 strains of Klebsiella pneumoniae,16 strains of Escherichia coli,5 strains of Pseudomonas aeruginosa,3 strains of Haemophilus influenzae,2 strains of Proteus mirabilis and 2 strains of Enterobacter).Streptococcus pneumoniae had higher sensitivity rates to chloramphenicol(100.0％),clindamycin(97.0％)and cefoxitin(93.9％),and had higher resistance rates to oxacillin(93.9％),tetracycline(87.9％),doxycycline(84.9％)and penicillin(80.8％).Staphylococcus aureus had higher sensitivity rates to chloramphenicol(100.0％),clindamycin(96.2％),compound sulfamethoxazole tablets(92.3％)and cefoxitin(92.3％),and had higher resistance rates to oxacillin(93.9％)and penicillin(80.8％).Klebsiella pneumoniae had higher sensitivity rates to gentamicin(94.9％),azithromycin(92.3％),chloramphenicol(89.5％)and ciprofloxacin(84.6％),and had higher resistance rates to cefoxitin(100.0％),amoxicillin-clavulanic acid(94.9％),compound sulfamethoxazole tablets(92.3％),tetracycline(87.2％)and doxycycline(87.2％).Among 126 strains of respiratory pathoges bacteria,69(54.7％)were multi-drug resistant bacteria.Conclusion The positive rate of respiratory pathogen culture in OSAHS patients with pneumonia is 39.4％and the common respiratory pathogens are Klebsiella pneumoniae,Streptococcus pneumoniae and Staphylococcus aureus.Streptococcus pneumoniae have higher resistance rates to oxacillin,tetracycline,doxycycline and penicillin.Staphylococcus aureus have higher resistance rates to oxacillin and penicillin.Klebsiella pneumoniae have higher resistance rates to cefoxitin,amoxicillin-clavulanic acid,compound sulfamethoxazole tablets,tetracycline and doxycycline,and the proportion of multidrug-resistant bacteria is relatively high.
万方数据
维普
