Relationship between Fibrinogen and Endothelial Function Indexes and Vascular Restenosis in Patients with Arteriosclerosis Obliterans of Lower Extremities after Endovascular Intervention Therapy
Objective To explore the relationship between fibrinogen(FIB)and endothelial function indexes and vascular restenosis in patients with arteriosclerosis obliterans of lower extremity(LEASO)after endovascular intervention therapy.Methods One hundred and sixteen patients with LEASO admitted to Affiliated Hospital of Hebei University from May 2021 to September 2022 were retrospectively selected as the study subjects.Clinical data of the patients was collected,and patients were divided into the restenosis group(n=51)and the non-restenosis group(n=51)according to whether they had undergone revascularization.Multivariate Logistic regression analysis was used to explore the influencing factors of vascular restenosis in patients with LEASO after endovascular intervention therapy,and restricted cubic spline regression analysis was used to analyze the dose-response relationship between FIB,endothelin-1(ET-1),nitric oxide(NO)and the risk of vascular restenosis in patients with LEASO after endovascular intervention therapy.Results The tumor necrosis factor-alpha(TNF-α),C-reactive protein(CRP),C-reactive protein/albumin ratio(CAR),FIB,and ET-1 in the restenosis group were higher than those in the non-restenosis group,while albumin and NO were lower than those in the non-restenosis group(P＜0.05).Multivariate Logistic regression analysis showed that TNF-α,CRP,albumin,CAR,FIB,ET-1,and NO were independent influencing factors of vascular restenosis in patients with LEASO after endovascular intervention therapy(P＜0.05).Restricted cubic spline regression analysis showed that there was a nonlinear dose-response relationship between FIB,ET-1,and NO and the risk of vascular restenosis in patients with LEASO after endovascular intervention therapy(P=0.614,Pnonlinear=0.012;P=0.285,Pnonlinear=0.003;P=0.417,Pnonlinear=0.005),with the increase of FIB and ET-1 and the decrease of NO,the risk of vascular restenosis in patients with LEASO after endovascular intervention therapy increases non proportionally.Conclusion Increased FIB and ET-1 are risk factors of vascular restenosis in patients with LEASO after endovascular intervention therapy,while decreased NO is a protective factor of vascular restenosis in patients with LEASO after endovascular intervention therapy.FIB,ET-1,and NO all have a nonlinear dose-response relationship with the risk of vascular restenosis in patients with LEASO after endovascular intervention therapy.
Arteriosclerosis obliteransArteriosclerosis obliterans of lower extremityEndovascular proceduresFibrinogenEndothelin-1Nitric oxideVascular restenosis
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