Effect of Timing of Treatment with Sivelestat Sodium on Patients with Sepsis Induced Acute Respiratory Distress Syndrome
Objective To investigate the effect of timing of treatment with sivelestat sodium on patients with sepsis induced acute respiratory distress syndrome.Methods A total of 52 patients with sepsis induced acute respiratory distress syndrome admitted to Xuzhou Municipal Hospital,Xuzhou Medical University from January 2021 to February 2024 were selected.The patients were divided into group A(n=32),group B(n=9)and group C(n=11)based on timing of treatment with sivelestat sodium.After admission,patients were given routine treatments such as anti infection,nutritional support,electrolyte balance maintenance,and anticoagulation.Based on this,they were given sivelestat sodium for injection.Group A was treated within 24 hours of onset,group B was treated between 24-48 hours of onset,and group C was treated after 48 hours of onset.Three groups were all treated for 5 days.Clinical efficacy at 5 days after treatment was evaluated,blood gas analysis indicators[oxygenation index,partial pressure of carbon dioxide(PaCO2),and arterial oxygen saturation(SaO2)]before treatment and at 5 days after treatment were detected,Sequential Organ Failure Assessment(SOFA)score and Acute Physiological and Chronic Health Evaluation n(APACHE Ⅱ)score before treatment and at 5 days after treatment were evaluated,and the occurrence of adverse reactions was recorded.Results At 5 days after treatment,the total effective rate in group A was higher than that in group B and group C(P＜0.05).At 5 days after treatment,the oxygenation index,SaO2 in group A were higher than those in group B and group C,PaCO2 in group A was lower than that in group B and group C(P＜0.05).At 5 days after treatment,the SOFA score,APACHE Ⅱscore in group A were lower than those in group B and group C(P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions among the three groups(P＞0.05).Conclusion Sivelestat sodium within 24 hours of onset can improve the clinical efficacy of patients with sepsis induced acute respiratory distress syndrome,improve blood gas analysis indicators,and disease severity,and its safety is acceptable.
万方数据
维普
